Long-lasting neuronal desynchronization caused by coordinated reset stimulation
نویسندگان
چکیده
منابع مشابه
Long-lasting neuronal desynchronization caused by coordinated reset neuromodulation
A number of brain diseases, e.g. movement disorders such as Parkinsons disease, are characterized by abnormal neuronal synchronization. Within the last years permanent high-frequency (HF) deep brain stimulation became the standard therapy for medically refractory movement disorders. To overcome limitations of standard HF deep brain stimulation, we use a model based approach. To this end, we mak...
متن کاملMulti-frequency activation of neuronal networks by coordinated reset stimulation.
We computationally study whether it is possible to stimulate a neuronal population in such a way that its mean firing rate increases without an increase of the population's net synchronization. For this, we use coordinated reset (CR) stimulation, which has previously been developed to desynchronize populations of oscillatory neurons. Intriguingly, delivered to a population of predominantly sile...
متن کاملDesynchronization boost by non-uniform coordinated reset stimulation in ensembles of pulse-coupled neurons
Several brain diseases are characterized by abnormal neuronal synchronization. Desynchronization of abnormal neural synchrony is theoretically compelling because of the complex dynamical mechanisms involved. We here present a novel type of coordinated reset (CR) stimulation. CR means to deliver phase resetting stimuli at different neuronal sub-populations sequentially, i.e., at times equidistan...
متن کاملOptimal number of stimulation contacts for coordinated reset neuromodulation
In this computational study we investigate coordinated reset (CR) neuromodulation designed for an effective control of synchronization by multi-site stimulation of neuronal target populations. This method was suggested to effectively counteract pathological neuronal synchrony characteristic for several neurological disorders. We study how many stimulation sites are required for optimal CR-induc...
متن کاملCoordinated reset vibrotactile stimulation shows prolonged improvement in Parkinson's disease
Coordinated reset stimulation delivers brief high-frequency trains in a patterned sequence and may reset the phases of neuronal subpopulations toward a desynchronized state. Studies have shown that peripheral vibrotactile stimulation accesses central sensory networks and produces a characteristic cortical response. In this study, we investigated the tolerability and efficacy of peripheral vibro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2011
ISSN: 1471-2202
DOI: 10.1186/1471-2202-12-s1-k3